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Fig. 3. | Journal of Experimental & Clinical Cancer Research

Fig. 3.

From: C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Fig. 3.

C3 expression is correlated with CAF activation and function in human breast cancer. The relationship between the mRNA transcripts for C3 and phenotypic markers of CAF (a-c, PDGFRA, ACTA2, FAP), functional cytokines (d-f, TGFB1, CXCL12, HGF,) and ECM components (g-l, Fn1, Col8a1, IGFBP3, CCN2, NGFR, SPON1) were determined by Pearson’s correlation analyses. Expression data for these genes in invasive breast cancer patients were obtained from the cBio Cancer Genomics Portal database (n = 526). Data were analyzed three times

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