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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

Fig. 4

Effects of SIRT7 on tumor xenografts in nude mice. a 22RV1 cells with stable SIRT7 silencing by shRNA (shNC and shSIRT7) were injected subcutaneously into the axillae of nude mice. Mice were sacrificed and their tumors were photographed after 28 days. b Xenograft tumors were measured every 3 days. Vtumor = 0.5 × L × W2. c Mice were sacrificed after 28 days and their tumor masses were excised and weighed. d Xenograft samples were subjected to Ki67 and LC3B staining. Scale bar, 50 μm. e 22RV1 cells with stable SIRT7 silencing by shRNA (shNC and shSIRT7) were used in a metastasis model assay induced by tail vein injection. Luminescence of 22RV1 cells was evaluated by an in vivo imaging system. f Representative lung metastasis samples were stained with AR. Scale bar, 50 μm. P-values were calculated by t-test (*P < 0.05; **P < 0.01; ***P < 0.001)

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