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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Targeting hypoxia in tumor: a new promising therapeutic strategy

Fig. 1

Schematic representation of the effects of intratumoral hypoxia in human diseases. a Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that consists of a constitutively expressed HIF-1β subunit and a HIF-1α subunit regulated via O2-independent mechanisms. Activated HIF-1 transcription factor binds the hypoxia response elements (HRE) to induce transcription of target genes involved in angiogenesis, glucose metabolism, cell proliferation/survival and invasion/metastasis, etc., as described in the panels. b Schematic representation of the number of scientific papers about HIF-1, published in the last 15 years, and the relative diseases

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