Fig. 1
From: Targeting hypoxia in tumor: a new promising therapeutic strategy
Schematic representation of the effects of intratumoral hypoxia in human diseases. a Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that consists of a constitutively expressed HIF-1β subunit and a HIF-1α subunit regulated by O2-dependent mechanisms. Activated HIF-1 transcription factor binds to the hypoxia response elements (HRE) to induce transcription of, among others, target genes involved in angiogenesis, glucose metabolism, cell proliferation/survival, and invasion/metastasis. b Schematic representation of the number of scientific papers related to HIF-1, published in the last 25 years, and the relative diseases