Fig. 8

Arnidiol inhibits tumor growth in a MDA-MB-231 xenograft mouse model. a Comparison of the overall survival of mice between vehicle, Arn (40 mg/kg) and Arn (80 mg/kg) (n = 10 mice per group). Statistical significance in survival was determined by log-rank test. ^**P < 0.01 or ^***P < 0.001 compared with control. b Average tumor volume in mice treated with vehicle, Arn (40 mg/kg) and Arn (80 mg/kg) (n = 6 mice per group). ^*P < 0.05, ^**P < 0.01 or ^***P < 0.001 compared with control. c Body weight of mice during the 30 days of treatment. d Tumor tissues were sectioned and subjected to H&E, TUNEL, and immunohistochemistry analyses for determination of morphology, apoptosis, and the expression of C-Caspase 3