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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis

Fig. 8

Proposed model of the CLDN6/HIF-1α negative regulatory feedback mechanism. HIF-1α is stabilized under hypoxia and heterodimerises with HIF-1β to bind to the HRE sequences within the promoter of CLDN6, which is increased at both the mRNA and protein levels. In the cytoplasm, CLDN6 combines and retains β-catenin, a transcription factor of SENP1, causing the degradation of β-catenin and its inability to translocate to the nucleus, which reduces SENP1 expression and prevents the deSUMOylation of HIF-1α, ultimately leading to HIF-1α degradation and breast cancer metastasis suppression

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