Fig. 2
From: From single gene analysis to single cell profiling: a new era for precision medicine
Single-cell transcriptomic of Chronic Myeloid Leukaemia Stem Cells (CML-SCs). The simultaneous single-cell mutation detection and RNA sequencing obtained by the novel BCR-ABL-targeted Smart-seq-2 protocol (BCR-ABL tSS2) permitted to study CML-SCs heterogeneity and to identify a subpopulation of resistant SCs, otherwise not possible through cell-population analysis. This approach allows to identify in resistant cells a number of dysregulation in genes and pathways which could be useful to predict disease response to therapy and targeted for precision medicine