Fig. 1

Expression levels of urinary and tissue let-7c miRNA cluster in a cohort of HG-NMIBC patients. Box-Plot diagrams of relative miRNA expression levels, performed by qRT-PCR in urine supernatant (a) and in tissue (b). Boxes define the 25th and 75th percentiles; the horizontal lines into within the boxes indicates the median, and bars define the minimum and maximum values. Relative miRNAs expression was normalized to Unisp2 spike-in for urine and U6 snRNA for tissue and calculated using the comparative ∆Ct method. P-value was determined using the Mann-Whitney rank sum test