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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression

Fig. 5

Linc01134 stabilizes YY1 mRNA through recruiting IGF2BP1. a Pearson correlation analysis of IGF2BP1 and YY1 in LIHC tissues. b-c qRT-PCR examined the expression of IGF2BP1 and YY1. d qRT-PCR using α-amanitin (50 μM) was performed to measure the effects of knocking down IGF2BP1 on the stability of YY1 and GAPDH (control). e-f. RIP and RNA pull down were performed to investigate the interaction between IGF2BP1 and YY1 mRNA, as well as between IGF2BP1 and linc01134. g RIP assay detected the relative enrichment od YY1 in anti-IGF2BP1 group when silencing linc01134. h qRT-PCR using α-amanitin (50 μM) was performed to measure the stability of YY1 mRNA in differently transfected groups. GAPDH was internal reference. i qRT-PCR detected the expression of YY1 in differently transfected groups. **P < 0.01. n.s. meant no significance

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