Fig. 1
From: Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation
Expression of CUL7 is associated with tumor grade and patient survival in gliomas. a Quantification of CUL7 mRNA expression levels in GBMs and normal brain tissues in TCGA. b Quantification of gliomas subtype-specific CUL7 expression in TCGA. Log2-transformed expression of CUL7 mRNA levels are listed on the Y-axis. Error bars represents the SEM. c ROC curve showing sensitivity of CUL7 as a marker to discriminate between mesenchymal subtype and non-mesenchymal subtype glioma patients. d Representative images of IHC staining for CUL7 in different grade gliomas and normal brain tissues (scale bar = 100 μm). e Western blot analysis of CUL7 levels in lysates from different grades of glioma tissues (WHO grades II–IV) and normal brain tissues. f Kaplan–Meier survival analysis for glioma patients with high CUL7 expression and low CUL7 expression in LGGs (n = 457) or GBMs (n = 141) in TCGA database. The cut-off level was set at the median value of the CUL7 levels. *P < 0.05; **P < 0.01; ***P < 0.001