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Table 2 IARC classification system for genetic variants

From: Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers

ClassDescriptionProbability of being pathogenic (5)Counseling consequences
1Benign< 0.001Consider as “no mutation detected”
2Likely benign0.001–0.049Consider as “no mutation detected”
3Uncertain0.05–0.949Survey depending on family history
4Likely pathogenic0.95–0.99Ascertained high risk regimen
5Pathogenic> 0.99Ascertained high risk regimen