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Table 5 VUS in the top 10 genes with the highest number of submitted variants

From: Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers

Gene

Variants

VUS

TTN

12,923

7859

BRCA2

10,941

5101

BRCA1

7614

2913

APC

6082

3114

NF1

4602

2046

TSC2

4563

1446

ATM

4266

2361

MSH6

4015

2209

MSH2

3296

1641

FBN1

3228

1011

  1. Data available on the ClinVar Miner website: https://clinvarminer.genetics.utah.edu/