Fig. 7

ETV6 directly binds to CRKL and positively regulates its expression. a CRKL overexpression increased ETV6 expression levels in HepG2, HCCLM3 and HuH7 cells. b CRKL knockdown decreased ETV6 expression levels in HepG2, HCCLM3 and HuH7 cells. c ETV6 knockdown decreased CRKL expression levels in CRKL-overexpressing HepG2, HCCLM3 and HuH7 cells. d Co-IP assays detected the direct interaction between ETV6 and CRKL