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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer

Fig. 1

HOST2 was upregulated in TNBC tissues and associated with poor survival. a The expression of HOST2 in collected 40 cases of TNBC tissues and matched non-cancerous breast tissues indicated by qRT-PCR analysis. b-d The expression of HOST2 in TNBC patients with advanced stage, lymph node metastasis and distant metastasis. e The expression of HOST2 was detected in different TNM stage by In situ hybridization analysis comparing with para-tumour tissue group respectively (200×). f The expression of HOST2 in breast cancer cell lines contrasted to MCF-10A group, data was normalized to MCF-10A group. g The correlation of HOST2 high expression or low expression with overall survival in TNBC patients determined by Kaplan-Meier analysis. h FISH assay revealed that HOST2 was mostly stained in TNBC cells’ cytoplasm (200×). i Subcellular fractionation demonstrated that HOST2 was enriched in the cytoplasm of TNBC cells. *P < 0.05, **P < 0.01, ***P < 0.001. All experiments were repeated three times

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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