Fig. 5

Let-7b, rather than miR-1266, inhibited TNBC cell invasion and STAT3 is a direct target of let-7b. a Effects of let-7b and miR-1266 overexpression on cell invasion in MDA-MB-231 and MDA-MB-468 cells detected by transwell invasion assay. b Pearson correlation analysis of the correlation of STAT3 expression with let-7b expression in the 40 TNBC samples. c, d The expression of STAT3 mRNA and protein after let-7b overexpression in TNBC cells detected by qRT-PCR and Western blot analysis. e The luciferase activity of STAT3-wt or STAT3-mut after co-transfection with let-7b mimics and STAT3-wt or STAT3-mut reporter vector. ^**P < 0.01, ^***P < 0.001