Fig. 6

Let-7b knockdown counteracted the tumour suppressing effects of si-HOST2 in TNBC cells. a-c Functional rescue experiments were carried out in MDA-MB-231 and MDA-MB-468 cells including MTT assay, colony formation assay, and transwell invasion assay. d Western blot analysis showed that knockdown of HOST2 decreased the expression of STAT3 and this effect was reversed by let-7b inhibitor in MDA-MB-231 and MDA-MB-468 cell lines. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001