Skip to main content
Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway

Fig. 6

Promotional effects of exosomal MALAT1 on CRC metastasis and tumorigenesis via fucosylation and PI3K/AKT/mTOR pathway in vivo (a) The location and intensity of fucosylation and FUT4 were presented in the lung metastatic models established by SW480 cells with different exosomes treatment. b Immunohistochemistry staining was used to measure the activity of PI3K/Akt/mTOR pathway in lung metastatic models. c Liver metastasis was conducted using SW480 cells treated with different exosomes and LTL&FUT4 co-staining were completed to show the fucosylation levels. d The activity and influence of PI3K/Akt/mTOR pathway in liver metastatic models was measured by immunohistochemistry staining. e The levels of fucosylation and FUT4 in the xenograft models were detected by immunofluorescence staining. f The activation of PI3K/Akt/mTOR pathway was further determined in the xenograft models. g Immunofluorescence staining was used to measure fucosylation and FUT4 levels in CRC samples with metastasis. h Immunohistochemistry staining was used to measure the activity of PI3K/Akt/mTOR pathway in clinical sample 2 and 4, comparing the CRC tissue and adjacent nontumor tissue

Back to article page