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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

Fig. 5

sFRP1 expression in HCC tissues. a, b The mRNA and protein expression levels of sFRP1 were measured in HSCs, L02 liver cells, and HCC cells. c, d The mRNA and protein expression levels of sFRP1 were upregulated in nontumoral liver tissues (NT) compared with HCC tissues (T), as measured by qRT-PCR and western blot analyses. e αSMA was highly expressed in NT. Using the median expression level of α-SMA in non-tumoral tissues as a threshold, the samples were classified into two groups. Compared with the low α-SMA group, sFRP1 was highly upregulated in the high α-SMA group. f Compared with the group with low NE levels in NT, sFRP1 was highly elevated in the group with high NE levels in NT. g Taking the median mRNA expression level of sFRP1 in the non-tumoral tissues as a threshold, we classified the cases into two groups: a low sFRP1 group and a high sFRP1 group. The snail, cyclin D1, c-Myc, Nanog, Wnt16B and E-cadherin in HCC tissues were assessed in the high versus low sFRP1 groups. *P < 0.05, **P < 0.01, *** P < 0.001

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