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Fig. 3. | Journal of Experimental & Clinical Cancer Research

Fig. 3.

From: Exosomal miRNAs in tumor microenvironment

Fig. 3.

The mechanism of immune microenvironment reshaping by exosomal miRNAs. Exosomes secreted by the primary tumor cells are taken up by the receptor immune cells, wherein the exosomal miR-212-3p target the MHC class II TF RFXAP complexus and activate the HLA-DR, -DP, and -DQ molecules. The exosomal miRNAs (miR-222-3p, miR-21, miR-10a, etc.) target the proteins (SOCS3, PTEN, RORA, etc.) and activate the molecules (p-STAT3, p-p65, p-AKT, p53, etc.). These exosomal miRNAs reshape inmune microenvironment by mediating immunosuppression.

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