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Table 1 The relationship between GLYR1 expression and CRC clinicopathological features

From: Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

 

No.of cases

Low

Medium

High

χ2 value

P-value

Frequency

221 (100%)

44 (19.9%)

64 (29.0%)

113 (51.1%)

 

Age

 Younger (< 60 years)

118 (53.4%)

24 (20.3%)

36 (30.5%)

58 (49.2%)

0.427

0.808

 Older (> = 60 years))

103 (46.6%)

20 (19.4%)

28 (27.2%)

55 (53.4%)

  

Gender

 Male

135 (61.1%)

26 (19.3%)

42 (31.1%)

67 (49.6%)

0.781

0.677

 Female

86 (38.9%)

18 (20.9%)

22 (25.6%)

46 (53.5%)

  

Position

 Colon

150 (67.9%)

38 (25.3%)

45 (30.0%)

67 (44.7%)

10.890

0.004

 Rectum

71 (32.1%)

6 (8.4%)

19 (26.8%)

46 (64.8%)

  

Tumor sise (maximum diameter)

 < 5 cm

106 (48.0%)

8 (7.5%)

34 (32.1%)

64 (60.4%)

19.726

< 0.001

 > =5 cm

115 (52.0%)

36 (31.3%)

30 (26.1%)

49 (42.6%)

  

Tumor grade (diffrentiation)

 G1

27 (12.2%)

1 (4.8%)

6 (28.6%)

14 (66.7%)

33.570

< 0.001

 G2

173 (78.3%)

27 (15.6%)

51 (29.5%)

95 (54.9%)

  

 G3

21 (9.5%)

16 (59.3%)

7 (25.9%)

4 (14.8%)

  

Invasive depth

 Submucosal

14 (6.4%)

0 (0.0%)

6 (42.9%)

8 (57.1%)

9.586

0.143

 Myometrium

21 (9.5%)

2 (9.5%)

6 (28.6%)

13 (61.9%)

  

 Subserosal

92 (41.6%)

16 (17.4%)

26 (28.3%)

50 (54.3%)

  

 Break the serosa

94 (42.5%)

26 (27.7%)

26 (27.7%)

42 (44.6%)

  

Mucinous component

 Absent

165 (74.7%)

21 (12.7%)

52 (31.5%)

92 (55.8%)

21.066

< 0.001

 Present

56 (25.3%)

23 (41.1%)

12 (21.4%)

21 (37.5%)

  

Microsatellite instability

 MSS

164 (74.2%)

7 (4.3%)

48 (29.3%)

109 (66.4%)

107.823

< 0.001

 MSI-L

6 (2.7%)

4 (66.6%)

1 (16.7%)

1 (16.7%)

  

 MSI-H

51 (23.1%)

33 (64.7%)

15 (29.4%)

3 (5.9%)

  

Lymphatic metastasis

 Negative

131 (59.3%)

27 (20.6%)

41 (31.3%)

63 (48.1%)

1.268

0.530

 Positive

90 (40.7%)

17 (18.9%)

23 (25.6%)

50 (55.5%)

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