Fig. 6

Sur-X inhibited tumor growth in xenograft mouse models. a Schematic of subcutaneous xenograft mouse model with intravenous injection. b Picture (left) and volume (right) of tumor nodules of mice from Sur-X group and Con group. n = 5; **, p < 0.01. c Body weight of mice from two groups. n = 5; ns, not significant. d Representative HE staining sections of heart, liver and kidney of mice from Sur-X group and Con group. Three independent experiments were performed. Scale bars, 200 μm. e Representative IHC staining of survivin, XIAP in tumors of mice from two groups (left), and 5 non-overlapping fields were randomly selected for the analysis of their expression in two groups, Chi-square test was performed to examine the difference (right). Scale bars, 100 μm. ****, p < 0.0001. Three independent experiments were performed. f TUNEL staining in tumors of mice from two groups. Scale bars, 100 μm. Three independent experiments were performed. g The representative HE staining pictures of tumor tissues from two groups. Scale bar, 50 μm. Three independent experiments were performed. h Representative IHC staining of MLKL in tumors of mice from two groups, and 5 non-overlapping fields were randomly selected for the analysis of MLKL expression in two groups, Chi-square test was performed to examine the difference (right). Scale bars, 100 μm. ****, p < 0.0001. Three independent experiments were performed