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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer

Fig. 8

Association of TP53INP1 expression with MSI2 expression. a Immunohistochemistry. TNBC tissues were subjected to immunohistochemical staining of MSI2 and TP53INP1. Representative images were acquired with 10× and 20× objectives. Scale bar, 100 μm and 200 μm. b Plot depicting the positive correlation between MSI2 protein expression and TP53INP1 protein expression in TNBC. c Kaplan-Meier survival curves comparing OS of breast cancer combined with MSI2 mRNA and TP53INP1 mRNA expression. d Kaplan-Meier survival curves comparing OS of breast cancer combined with MSI2 mRNA and TP53INP1 mRNA expression. e A schematic model of MSI2/TP53INP1 function during TNBC metastasis. Normally, MSI2a interacts with the 3’UTR of TP53INP1 mRNA, leading to the stabilization of TP53INP1 mRNA, which in turn ensures complete p-ERK inactivation. In the case of MSI2a dysregulation in TNBC, TP53INP1 mRNA becomes unstable, resulting in decreased TP53INP1, inevitably causing increased p-ERK and TNBC metastasis

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