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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells

Fig. 1

PGCCs with budding daughter cells in HEY and BT-549 cells. a HEY and BT-549 control cells and PGCCs. (a) HEY control cells, (b) HEY PGCCs induced by 450 μM CoCl2 treatment for 48 h, (c) PGCCs and their daughter cells; the large black arrow indicates PGCCs and the small black arrow heads the daughter cells, (d) BT-549 control cells, (e) BT-549 PGCCs induced by 450 μM CoCl2 treatment for 24 h, and (f) PGCCs and their daughter cells; the large black arrow indicates PGCCs and the small black arrow heads the daughter cells. b H&E staining of the HEY and BT-549 cells before and after CDC25i. (a) HEY control cells, (b) Control cells after CDC25C knockdown, (c) HEY PGCCs with daughter cells, (d) HEY PGCCs and daughter cells after CDC25C knockdown, (e) BT-549 control cells, (f) Control cells after CDC25C knockdown, (g) H&E staining of the BT-549 PGCCs with daughter cells, and (h) BT-549 PGCCs with daughter cells after CDC25C knockdown c (a) The percentage of HEY PGCCs in control, control cells after CDC25i, PGCCs with daughter cells, and PGCCs with daughter cells after CDC25Ci. (b) The percentage of BT-549 PGCCs in control, control cells after CDC25i, PGCCs with daughter cells, and PGCCs with daughter cells after CDC25Ci. All magnifications are at 100×. Treatment: Cells treated with CoCl2. 1531si: siRNA CDC25C-1531

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