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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells

Fig. 5

a Co-IP shows the interaction between pCDC25CSer216, pCDC25CSer198, and P53 in HEY and BT-549 cells. Western blot showed the interaction between (a) pCDC25CSer216 and P53 and (b) pCDC25CSer198 and P53. b The levels of total protein expression of CDC25C, pCDC25CSer216, and pCDC25CSer198 in HEY and BT-549 control and PGCCs with daughter cells transfected with p53i, siRNA control, and negative control. c Expression of P53 and pCDC25CSer216 in human breast cancer (IHC, × 100). Breast cancer tissue with (a) P53 and (b) pCDC25CSer216 positive expressions. Breast cancer tissue with (c) P53 and (d) pCDC25CSer216 negative expressions. d Expression of P53 and pCDC25CSer216 in human ovarian tumor (IHC, 100×). Ovarian cancer tissue with (a) P53 and (b) pCDC25CSer216 positive expressions. Ovarian carcinoma with (c) P53 and (d) pCDC25CSer216 negative expressions. Treatment: Cells treated with CoCl2. 339: siRNA p53–339

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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