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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway

Fig. 5

ERK phosphorylation is critical for ABCA8-induced HCC progression. a Western blot analysis of ABCA8, ERK, p-ERK, EMT markers and ZEB1 in indicated cells. b Proliferation rate after SCH722984 treatment was analyzed by CCK-8 assay of indicated HCC cells. c Representative images of colony formation assays are shown on the top; the number of foci counted are shown on the bottom. d Transwell invasion assays for indicated cell lines are shown on top, Scale bars: 200× = 50 μm; counts of invaded HCC cells are shown on the bottom. ) Wound-healing assay for indicated cell lines. Data are means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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