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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway

Fig. 7

ABCA8 is regulated by miR-374b-5p and inhibits the progression of HCC via the ERK/ZEB1 axis. a Western blot analysis of the effects of miR-374b-5p and ABCA8 on ERK/ZEB1 axis induced EMT. Overexpression of ABCA8 in Huh7-mir-374b-5p cells can weaken the phosphorylation of ERK and inhibit EMT. In contrast, silencing ABCA8 in HCCLM3-anti-mir-374b-5p cells enhance the phosphorylation of ERK and induce EMT. b Representative images of colony formation assays for indicated cells. c Transwell invasion assays for indicated cell lines are shown on top, Scale bars: 200× = 50 μm; counts of invaded HCC cells are shown on the bottom. d Schematic representation of the mechanism underlying ABCA8-mediated HCC progression. Data are means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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