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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Long non-coding RNA LINC00520 promotes the proliferation and metastasis of malignant melanoma by inducing the miR-125b-5p/EIF5A2 axis

Fig. 4

ceRNA analysis of LINC00520. a Cytoscape was used to visualize LINC00520-miRNA-target gene nectworks based on our miRNA-seq and RNA-seq data. The interaction between LINC00520 and miRNAs was predicted through miRcode. TargetScan, miRDB and miRTarBase were used to find the target genes of miRNAs. Red color correspond to high expression, and blue color correspond to low expression. b The miR-125b-5p expression were detected in 38 malignant melanoma tissues. c The expression of miR-125b-5p was analyzed by using GEO#GSE24996 dataset. d The expression of miR-125b-5p was detected in GEO#GSE34460 dataset. e The expression of EIF5A2 was analyzed in 38 malignant melanoma tissues and ANT. f The expression of EIF5A2 was detected from TCGA by using GEPIA (http://gepia.cancer-pku.cn/). g The correlation of LINC00520 and miR-125b-5p in 38 melanoma tissues was negative. h The positive correlation between LINC00520 and EIF5A2 mRNA in 38 melanoma tissues. i A negative correlation between LINC00520 and miR-125b-5p expression were found in TCGA melanoma dataset. j The positive correlation between LINC00520 and EIF5A2 mRNA levels in TCGA melanoma dataset. Data were expressed as the mean ± SD, *P < 0.05, ***P < 0.001

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