Fig. 6

Verteporfin treatment inhibited tumor development in E6-E7 knock-in mice with 4NQO-induced OSCC. a Schema of 4NQO-induced OSCC transgenic mice model that were treated with VP (100 mg/kg) at a 3-day interval for 6 doses. b, c Representative images of tongue lesions, lesions size and number in Vehicle-treated or VP-treated mice (n = 8 per group). d Representative images of H&E staining from tumors of Vehicle-treated or VP-treated mice. Scale bars, 50 μm. e Expressions of CCL2 and CD163 by qRT-PCR in tumors of Vehicle-treated or VP-treated mice. Quantitative analysis based on triplicate experiments. Results were presented as means ± SD. *P<0.05, **P<0.01, ***P<0.001