Fig. 1

TACE resistance is associated with alteration in glucose metabolism specifically through the enrichment of PKM2: (a) Schematic outline of the identification of 105 genes differentially expressed genes between TACE responders and non-responders which also correlate with the TACE Navigator gene signature. (b) Heatmap demonstrating the clustering of TACE responders and non-responders based on the 105 correlated genes. (c) KEGG pathway gene set enrichment analysis of 105 correlated survival related genes demonstrating alterations in glucose metabolism as a potential pathway associated with TACE resistance. (d) Schematic representation of the glycolysis and gluconeogenesis pathways highlighting the genes G6PC, PCK1 and PKM2, all of which correlate with the TACE Navigator signature. e Relative expression of PKM2 between TACE responders and non-responders with associated survival analysis