Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: ACYP2 contributes to malignant progression of glioma through promoting Ca2+ efflux and subsequently activating c-Myc and STAT3 signals

Fig. 7

ACYP2 promotes tumor growth in nude mice. a, Growth curves of different xenograft tumors during the administration. Data are shown as mean ± SD (n = 5/group). Day 0th represents time point of tumor cell injection, and day 3th represents the beginning of dosing by intraperitoneal injection. b, Left and right panels show photographs of dissected tumors and mean tumor weight from the indicated groups, respectively. c, Western blot analysis was performed to analyze the levels of the indicated proteins in the xenigraft tumors from representative mice. GAPDH was used as a loading control. d, Representative sections from the indicated groups were subjected to IHC staining using corresponding antibodies. Histogram represents mean ± SD of the percentage of ACYP2, c-Myc, NCL and p-STAT3705-positive cells from five microscopic fields in each group, as shown in right panel. e, Shown is representative Ki67 staining of xenograft tumors from the indicated groups (left panel). Histogram represents mean ± SD of the percentage of Ki67 positive cells from five microscopic fields in each group, as shown in right panel. Scale bar, 200 μm. **, P < 0.01 for comparison with shNC; ##, P < 0.01 for comparison with shACYP2 + BAPTA-AM or Calpeptin

Back to article page