Skip to main content
Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling

Fig. 1

Upregulated SALL4 in ccRCC promotes tumor progression and indicates poor prognosis. a Relative SALL4 expression in normal kidney and ccRCC tissues. b Differential expression of SALL4 in 407 paired tissues from ccRCC patients. Data (a, b) were acquired from TCGA Renal 2 dataset via Oncomine database. c Representative IHC images of SALL4 in normal kidney and ccRCC tissues (scale bar, 20 μm). d-h High expression of SALL4 was positively correlated with tumor progression. Varied expression of SALL4 depending on tumor invasion (d), lymphatic metastasis (e), distant metastasis (f), histological grade (g) and AJCC stage (h). i-k Kaplan-Meier analysis of overall survival in ccRCC patients based on SALL4 expression. l-o Area under ROC curve (AUROC) analyses were performed to determine the diagnostic potential for indicated ccRCC patients. Data were acquired from TCGA Renal 2 dataset via Oncomine database. * P < 0.05, ** P < 0.001 and *** P < 0.001

Back to article page