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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling

Fig. 3

SALL4 promotes ccRCC cells migration and invasion in vitro. a, c Cell migration ability was evaluated by wound healing assays in ACHN (a) and 786-O (c) cells with indicated shRNA treatment (scale bar, 200 μm). b, d Transwell migration and matrigel invasion assays were conducted to determine the cell migration and invasion capabilities in ACHN (b) and 786-O (d) cells treated as indicated (scale bar, 100 μm). e-h Scatter plot analyses were performed to determine the correlation between SALL4 and MMP9 (e), MMP25 (f), TIMP3 (g) and TIMP4 (h) mRNA expression levels in 533 ccRCC patients from TCGA database. Data were analyzed via LinkedOmics bioinformatics. ** P < 0.001 and *** P < 0.001

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