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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling

Fig. 5

SALL4 downregulation attenuates the activation of Akt/GSK-3β signaling and VEGFA expression in ccRCC. a, b Western blot analyses for protein levels of total Akt (t-Akt), phosphorylated Akt (p-Akt), total GSK-3β (t-GSK-3β), phosphorylated GSK-3β (p-GSK-3β) and VEGFA in ACHN (a) and 786-O (b) cells with indicated treatment. c Immunofluorescence staining of p-Akt and p-GSK-3β in ACHN (left) and 786-O (right) cells with indicated treatment (scale bar, 50 μm)

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