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Table 2 Cox regression analysis of prognostic factors associated with overall survival of ccRCC patients (n = 200)

From: VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling

Parameters Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Age
 < 60 1.354 0.846–2.168 0.207
 ≥ 60       
Sex
 Male 1.062 0.670–1.683 0.800
 Female       
T stage
 T1-T2 3.529 2.217–5.618 < 0.001 2.377 0.945–5.983 0.066
 T3-T4       
N stage
 N0 2.149 1.071–4.312 0.031 0.726 0.332–1.589 0.423
 N1+       
M stage
 M0 5.290 3.291–8.502 < 0.001 4.375 2.381–8.038 < 0.001
 M1+       
Tumor Grade
 Grade 1–2 2.451 1.485–4.047 < 0.001 1.190 0.674–2.102 0.548
 Grade 3–4       
AJCC stage
 Stage I-II 3.776 2.326–6.128 < 0.001 0.967 0.355–2.639 0.948
 Stage III-IV       
SALL4 level
 Low 2.058 1.289–3.285 0.003 1.844 1.129–3.012 0.015
 High