Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways

Fig. 2

Collective migration of squamous cancer cells (SCCs) is driven by the matrix-dependent mechano-sensitization of EGF signaling. a Collective migration of epithelial tumor cells is a tissue-driven process dictated by ECM remodeling, which is orchestrated by CAFs. CAFs lead the way for cancer cells by digging tracks within the ECM that SCCs use to invade [70, 71]. b Calcium ions are intracellular second messengers that modulate actomyosin contractility. ECM stiffness and activation of the EGFR signaling pathway increase intracellular calcium concentration mediated by Cav1.1 expression in SCCs [70]. EGF stimulation promotes myosin light chain 2 (MLC2) phosphorylation only when SCCs are exposed to ECM stiffness. Note that ‘p’ indicates phosphorylation

Back to article page