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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4

Fig. 6

The expression level of miR-424 is inversely correlated with those of UNC5B and SIRT4 in bladder cancer. a miR-424 expression in bladder cancer tissues vs. normal ones. An open-access TCGA RNA-seq dataset containing 407 bladder cancers and 19 normal controls was employed in the present analysis. b miR-424 expression in low-grade bladder cancers vs. high-grade bladder cancers. The dataset in (a) was used in this analysis. c Kaplan-Meier survival analysis of TCGA bladder cancer dataset as in (a). d, e The correlation between the expression levels of miR-424 and UNC5B (D) or between those of miR-424 and SIRT4 (e) in an independent bladder cancer cohort (n = 30). f The working model of miR-424-mediated regulation of CDDP resistance of bladder cancer. Upon CDDP, HIF-1α is rapidly activated and up-regulates miR-424, which down-regulates pro-apoptotic UNC5B and SIRT4, and thereby bladder cancer cells become CDDP-resistant

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