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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer

Fig. 1

Tumour hypoxia, constitutive and alternative Pre-mRNA splicing. Schematic representations of: a tumour hypoxia, the mechanisms involved in promoting the hypoxic tumour microenvironment and resulting cellular tumour promoting hypoxic response, including hypoxia-induced alternative splicing; b splice site, intron and exon architecture and interaction with splicing factors and spliceosome components that select splice sites and eliminate intron sequences via the formation of a lariat structure, followed by the splicing together of exons; c constitutive pre-mRNA splicing and alternative splicing by cassette exons skipping, alternative 5′ splice site use, alternative 3′ splice site use, the use of mutually exclusive exons and by retaining introns; d ESE, ESS, ISE and ISS splice elements plus splicing factors down-regulated or up-regulated in cancer

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