Fig. 1

DIM can inhibit ESCC migration and invasion by reversal of EMT through modulation of AHR. a. Wound healing assay showed decreased ability of migration of both TE1 and KYSE150 cells. b. Transwell assay indicated DIM could inhibit invasion in a dose-dependent manner. c. Western blot implied that DIM could modulate AHR to reverse EMT process with downregulation of mesenchymal cell marker β-Catenin, Vimentin and Slug as well as MMPs and upregulation of epithelial cell marker Claudin-1. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance