Fig. 3

RhoA and ROCK1 in ESCC correlated with poor clinical outcomes and AHR expression levels. a. DIM could inhibit transcription of RhoA and ROCK1 in a dose-dependent manner. b. Representative IHC images of RhoA and ROCK1 expression levels in ESCC. c. RhoA and ROCK1 expression levels significantly correlated with lymph node metastasis and clinical stage. d. IHC staining-intensities positively correlated with levels of N stage. e. GEPIA database showed significant correlations among AHR, RhoA and ROCK1 in ESCA. f. Correlation analysis with IHC staining exhibited the same significant results as GEPIA. g. GSE38129 database verified that positive correlation among AHR, RhoA and ROCK1 expression levels in ESCC. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance