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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: 3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway

Fig. 4

Co-overexpression of AHR, RhoA and ROCK1 predicted poor prognosis and targeting RhoA/ROCK1 pathway can reverse EMT. a. Survival analysis of single AHR, RhoA or ROCK1 expression levels or combined. Co-overexpression of above three proteins predicted poor prognosis of ESCC. b. Knockdown of ROCK1 with specific siRNAs could reverse EMT process as well as downregulate expression of MMPs. c. Blockade of RhoA/ROCK1 pathway with inhibitor Fasudil could actually reverse EMT of ESCC. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance

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