Fig. 5
Targeting COX2/PGE2 pathway affects ESCC migration and invasion and overexpression of AHR promotes EMT process. a. GEPIA database showed positive correlations between PTGS2 (COX2) and AHR or RhoA or ROCK1. b. GEPIA database showed PTGS2 was overexpressed in ESCA. c. GSE23400 and GSE20347 verified PTGS2 expression levels in ESCC were elevated. d and e. Wound healing assay exhibited after COX2 selective inhibitor Celecoxib treatment, cell abilities of migration and invasion were inhibited while after PGE2 treatment, the abilities were strengthened. f and g. Overexpression of AHR could strengthen ESCC migration and invasion. H. Overexpression of AHR could promote EMT process. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance