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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: 3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway

Fig. 7

COX2/PGE2 pathway can be mediated by RhoA/ROCK1 pathway. a. Knockdown of AHR inhibited expression levels of RhoA, ROCK1 and COX2. b. After knockdown of AHR, DIM exerted no obvious effect on RhoA/ROCK1 and COX2 expression. c. Knockdown of ROCK1 inhibited expression of COX2. d. Inhibition of RhoA/ROCK1 pathway with Fasudil could suppress COX2 expression. e. Results by qPCR indicated Fasudil could inhibit transcription of RhoA/ROCK1 and COX2 expression in a dose-dependent manner. f. Knockdown of COX2 had no effects on ROCK1 expression levels. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance

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