Fig. 2

H19 promotes the metastasis of colorectal cancer cells in vitro and in vivo. a & b Overexpressed H19 promoted the migration and invasion of HCT116 and SW480 cells. c & d Knockdown of H19 inhibited the migration and invasion of HCT116 and DLD1 cells. e The Representative images of metastatic lung tumors after injection of HCT116-H19 and HCT116-Vector cells via tail vein in nude mice. Arrows represent metastatic tumors. f HE staining of metastatic lung tumors. g The number of metastatic tumors in the lungs of nude mice after injection of HCT116-H19 and HCT116-Vector cells. Scales bars = 100um. Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001