Fig. 7

CYT997 suppressed the tumor growth in gastric cancer PDX model. a 6 weeks old nude mice with subcutaneous implanted gastric cancer tumor were treated with control or CYT997 for 10 days. Tumor volumes of each group were measured in indicated days of treatment. **p < 0.01. b Images of gastric cancer PDX tumor of each group were presented at the same time of study ending. c Tumor weights in each group were measured at the end of the treatment and presented. **p < 0.01. d The expressions of p-JAK2, JAK2, p-STAT3, STAT3, PCNA and cleaved caspase 3 and LC3B was detected by western blotting in gastric cancer PDX tumor tissues. E The expression of p-STAT3, PCNA and cleaved caspase 3 and LC3B was detected by IHC in gastric cancer PDX tumor tissues. Scale bars = 50 μm. f Body weights of mice were recorded every other day. g HE staining of different tissues. Scale bars = 50 μm