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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling

Fig. 2

Sirt6 promoted growth of DLBCL. a, b Relative expression levels of Sirt6 were evaluated using quantitative PCR (mean ± SD, n = 3) and western blot in stably transfected LY1, LY8, and Val cells in contrast to empty vectors. c Sirt6 knockdown markedly decreased cellular proliferative activity. d Mice bearing shSirt6 cells were noted to have significantly reduced tumor volumes in contrast to samples transfected with empty vectors (n = 8 per group). e H&E and IHC staining of Ki-67 and Sirt6 were performed in xenograft tumor tissues. Bar = 50 μm. *p < 0.05; **p < 0.01; ***p < 0.001

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