Fig. 6

Knockdown of miR-497-5p reverses tumor growth and metastasis inhibition of BCCs induced by silencing CASC9. a Knockdown of miR-497-5p significantly reversed growth inhibition of BCCs transfected with shRNA-CASC9 in vitro. b and c Knockdown of miR-497-5p significantly reversed growth inhibition of BCCs transfected with shRNA-CASC9 in vivo. d Knockdown of miR-497-5p significantly reversed migration inhibition of BCCs transfected with shRNA-CASC9 in vitro. e Knockdown of miR-497-5p significantly reversed invasion inhibition of BCCs transfected with shRNA-CASC9 in vitro. f Knockdown of miR-497-5p significantly reversed FZD6 expression in xenograft transfected with shRNA-CASC9. g Knockdown of miR-497-5p significantly reversed Ki67 expression in xenograft transfected with shRNA-CASC9. h The schematic diagram of the oncogenic role of CASC9 in BC. The data are shown as the mean ± SD. *P < 0.05; **P < 0.01