Fig. 9

miR-130b-3p from M2 macrophage-derived EVs regulates the expression of GRHL2 by MLL3, thereby participating in GC progression. In GC, miR-130b-3p from M2 macrophage-derived EVs can target MLL3 expression. The downregulation of MLL3 promotes the reduction of H3K4me1 and H3K27ac enrichment in the GRHL2 enhancer, thereby inhibiting the expression of GRHL2, and ultimately promoting the survival of GC cells