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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression

Fig. 2

Effect of metformin on MICA and HSP70 protein expression. a Representative western blots and a bar chart showing HSF-1, MICA and HSP70 expression in SiHa and HeLa cell after 48 h treatment with metformin of different concentrations; b Representative flow cytometry showing MICA, MICB, ULBP1, ULBP2/5/6 and ULBP3 expression in the surface of SiHa and HeLa cell after 48 h treatment with 20 mM metformin. c Representative qRT-PCR showing MICA and HSP70 mRNA expression in SiHa and HeLa cell after 48 h treatment with 20 mM metformin. d Bar chart showing the enhanced killing rate of NK cells by metformin treatments. Data are presented as mean ± standard deviation, n = 3. *P < 0.05, and **P < 0.01, comparison with the 0 μM metformin treatment group

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