Fig. 3

Metformin influences the expression of PI3K (p110ɑ), phospho-PI3Kp55 (Tyr199), and phospho-Akt (ser473) in the PI3K/Akt pathway. a PI3K (p110ɑ), phospho-PI3Kp55 (Tyr199), and phospho-Akt (ser473) levels in SiHa and HeLa cell after 48 h treatment with metformin of different concentrations assessed by western blotting; b PI3K (p110ɑ), phospho-PI3Kp55 (Tyr199), and phospho-Akt (ser473) levels in SiHa and HeLa cells treated with and without metformin and LY29400 as measured by western blotting; c MICA and HSP70 expression in SiHa and HeLa cells treated with and without metformin and LY29400 as measured by western blotting. The data are presented as mean ± standard deviation, n = 3. *P < 0.05, and **P < 0.01, comparison with the 0 μM metformin treatment group