Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Table 1 Noncoding RNAs and their targets in aerobic glycolysis in HCC

Target	ncRNA	In vivo or in vitro	Involvement of other factors	Reference
GLUT	miR-342-3p	both	PI3K/AKT	[148]
	miR-505	both	IGF-1R	[149]
	miR-455-5p	both	IGF-1R/AKT	[150]
	lncRNA HOTAIR	both	mTOR	[151]
HK2、HK1	miR-139-5p	both	ETS1	[152]
	miR-34a	in vitro	p53	[153]
	miR-125b	both	–	[154, 155]
	Lnc-TUG1	in vitro	TUG1/miR-455-3p/AMPKβ2	[156]
	miR-199a-5p	both	PKM2	[157, 158]
	miR-885-5p	both	HIF-1α	[159]
PFK1、PFKFB3	miR-139-5p	both	ETS1	[152]
PFK1、PFKFB3	miR-520	both	TARDBP	[160]
PKM2	miR-122	both	–	[161]
	circMAT2B	both	miR-338-3p	[162]
	lncRNA LINC01554	both	Akt/mTOR	[163]
	miR-491–5p	both	–	[164]
	MiR-374b	in vitro	hnRNPA1	[165]
LDHA	miR-142-3p	both	–	[166]
LDHA	miR-34a	both	–	[167, 168]
HIF-1A	miR-199a-5p	both	–	[169]
HIF-1A	miR-3662	both	ERK/JNK	[170]
PI3K/Akt/mTOR	miR-125a	in vitro	–	[171]
PI3K/Akt/mTOR	miR-7	both	–	[172]
c-myc/STAT3	miR-23a	in vitro	PEPCK	[173]
c-myc/STAT3	miR-129-5p	both	PDK4	[174]
JAK/STAT	miR-196a /b	both	SOCS2	[175]
PPARγ	lncRNA Ftx	both	–	[176]
mTOR/TCF7L2	lncRNA MALAT1	in vitro	mTOR	[177]

ISSN: 1756-9966