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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling

Fig. 2

CPEB3 inhibits the TAM-induced EMT in CRC cells (a) Schema for stably transfected CRC cells treated with conditioned media from TAMs. (b) Cell Counting Kit-8 was used to quantify the number of HCT116-Ctrl/CPEB3 and LoVo-shCtrl/shCPEB3 cells, which were then cultured with supernatants from TAMs; error bars, SEM. (c) The invasion of HCT116-Ctrl/CPEB3 cells (co-cultured TAMs) was measured by a Transwell assay (200× magnification); error bars, SEM. (d) The invasion of LoVo-shCtrl/shCPEB3 cells (co-cultured TAMs) was measured by a Transwell assay (200× magnification); error bars, SEM. (e) The effect of the TAMs on the invasion of CRC cells (HCT116-Ctrl/CPEB3 and LoVo-shCtrl/shCPEB3) was analyzed by western blot analysis; error bars, SEM. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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